NMNH vs. NMN: What is NMNH and Its Further Anti-Aging Potential

The quest for health and beauty drives people to search for anti-aging supplements. The rapid use of such products makes a big shift in the anti-aging global market, with an expected revenue of 2,300 million by 2030[1].

Among the most effective anti-aging supplements, NMN (Nicotinamide Mononucleotide) and NMNH (Reduced Nicotinamide Mononucleotide) come to the top of the list.

However, you might wonder how NMNH differs from NMN and why NMNH holds greater potential in your body. Let’s get answers to all of your questions in detail below.

NMNH and NMNQuick Introduction

To delay aging and promote longevity, NMNH and NMN are widely used as natural supplements for your body’s health. They increase NAD+ (Nicotinamide Adenine Dinucleotide) levels in your body, which leads to healthy cell metabolism. People with high NMNH or NMN levels can suppress age-related tissue inflammation and enhance cognitive functions. Enlisted below are some of the key roles of these anti-aging supplements:

  • It promotes vitality and improves the overall well-being of a person.
  • It supports the body’s natural repair mechanism and helps individuals, especially older people, maintain a youthful appearance.
  • It maintains optimal health and helps fight the natural effects of aging.

What is NMNH?

1. Chemical Structure

NMNH is derived from the Nicotinamide Mononucleotide, a precursor to NAD+. The chemical formula for NMNH is C11H17N2O8P.

2. Relationship of NMNH to NMN

NMNH is a reduced form of NMN. Both NMNH and NMN are precursors to NAD+. However, both differ in their respective processes.

NMN has gained popularity for its anti-aging benefits due to its role as an NAD+ enhancer. NMNH promises enhanced benefits due to its faster-acting and longer-lasting effects. NMNH supplements are suggested to be more potent than NMN.

3. Main Functions of NMNH

Being an innovative supplement, NMNH serves a key role in various body functions, with a major focus on enhancing cellular health and fighting age-related problems. Here are some of the main functions of this supplement:

  • NMNH is a precursor to NAD+. By increasing NAD+ levels, NMNH supports essential metabolic functions and energy production within cells.
  • Higher NAD+ levels enhance mitochondrial efficiency, leading to improved energy production and cellular metabolism.
  • It is involved in the activation of enzymes like PARPs (Poly ADP-Ribose Polymerases), which are essential for DNA repair[2]. This way, it supports the natural DNA repair mechanism.
  • NMNH can be converted to NADH by NMNAT, and elevated levels of NADH can slow down cellular glycolysis and the TCA cycle[3].
  • It maintains the level of disodium salt and can improve insulin sensitivity and lipid metabolism.

NMNH vs. NMN

At this point, you have a basic understanding of the structure and functions of NMNH. However, one thing that still needs to be answered is the comparison of NMNH vs. NMN.

NMNH, as the reduced form of NMN, is characterized by the presence of an additional hydrogen atom in the phosphate group. This gives NMNH powder different chemical properties from NMN powder.

(1) Metabolism

NRH and NR are both effective precursors of NAD+, with NRH being more potent than NR. Supplementation of NMNH exhibits similar metabolic actions to NRH and can induce a significant increase in the levels of NR and NRH in cells[4]. In contrast, NMN cannot do this.

Furthermore, the metabolism of NMNH does not depend on the pathways of NRK and NAMPT[5].

(2) Effectiveness

NMNH is more effective than NMN. It can raise NAD+ levels more quickly and to a greater extent.

One study conducted on mammalian cells and mice[5] has demonstrated that NMNH leads to a rapid and sustained surge in NAD+ levels in whole blood. Compared to NMN, the effect of NMNH is faster and more long-lasting.

NMNH can also increase NAD+ levels in a variety of tissues, with the increase being greater than that of NMN. NMNH significantly elevates NAD+ levels in the liver, kidney, brain, muscle, brown adipose tissue, and heart. In contrast[5], the effect of NMN is somewhat limited.

(3) Bioavailability

NMNH may offer superior bioavailability.

As previously mentioned, NMNH could directly elevate NADH levels and be converted into NAD+ with greater efficiency within the body. NMNH helps to maintain more stable NAD+ levels and may be more readily absorbed and utilized by cells. 

In general, NMNH, as an emerging NAD+ enhancer, holds greater potential than NMN in enhancing cellular metabolic efficiency, boosting energy production, and combating the aging process.

BONTACWorld’s First NMNH Mass Production Supplier

With the increasing demand for various anti-aging supplements, many companies have started the mass production of this amorphous yellow powder.

Therefore, the real challenge lies in finding a reliable and trustworthy supplier. BONTAC helps you in this process by providing the most effective NMNH powder. They have launched the first batch of NMNH on the market globally and aim to manufacture more for their users.

The best thing about BONTAC NMNH is that it completes all index tests and production layouts, so you get the fastest access to the most efficient products. Established in 2012, this high-tech enterprise always delivers high-quality products and helps users with reliable services. Enlisted below are some of the outstanding advantages of BONTAC and its NMNH:

  • BONTAC NMNH is a more promising NAD+ enhancer, converted at a rate and concentration more than twice that of NMN
  • BONTAC NMNH is offered in both free acid and sodium salt forms, ensuring a purity level of no less than 99.5%
  • BONTAC is the world’s first to achieve large-scale manufacturing of NMNH and boasts leading enzymatic processes
  • Capitalizing on its strengths in green, low-carbon, and high-value-added bio-synthesis technology, BONTAC consistently delivers high-quality products and dependable services.
  • BONTAC NMNH can be widely used in the health industry, biomedicine, medical & beauty, green agriculture, and other fields.

Conclusion

NMNH is a great advancement in core biosynthetic science. It is exclusively manufactured to fight the natural decline in NAD+ levels associated with aging. With the help of NMNH, you can get more efficient and potent support for cellular energy production, DNA repair, and vitality.

Overall, it’s a next-generation alternative to traditional anti-aging supplements. BONTAC is a reliable supplier, aiming to deliver the most effective products and the most reliable supply to satisfy customers.

References:

[1] Anti-Aging Supplements Industry Prospective. Available at: https://www.zionmarketresearch.com/report/anti-aging-supplements-market (Accessed: 5 June 2024)

[2] Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism. Available at: https://www.frontiersin.org/articles/10.3389/fcell.2020.00246/full#B183 Accessed: 10 June 2024)

[3] Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. Available at: https://pubmed.ncbi.nlm.nih.gov/33793246/ (Accessed: 15 June 2024)

[4] NMNH is a more effective anti-aging material than NMN, Bontac world debut and mass production. Available at: https://www.bontac-bio.com/en/news-detail.aspx?id=8336&cid=50 (Accessed: 15 June 2024)

[5] Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. Available at: https://pubmed.ncbi.nlm.nih.gov/33724555/ (Accessed: 15 June 2024)


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